A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node--ablated, His bundle-paced dog.
Nolan, Emily R
A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node--ablated, His bundle-paced dog. [electronic resource] - Journal of pharmacological and toxicological methods - 1-10 p. digital
Publication Type: Journal Article
1056-8719
10.1016/j.vascn.2005.02.003 doi
Animals
Anti-Arrhythmia Agents--blood
Atrioventricular Node--surgery
Bundle of His--surgery
Cardiac Pacing, Artificial
Catheter Ablation
Cisapride--blood
Dogs
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical--methods
Electrocardiography--drug effects
Gastrointestinal Agents--blood
Histamine H1 Antagonists--blood
Ion Channels--antagonists & inhibitors
Long QT Syndrome--etiology
Male
Models, Animal
Models, Biological
Piperidines--blood
Pyridines--blood
Terfenadine--blood
A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node--ablated, His bundle-paced dog. [electronic resource] - Journal of pharmacological and toxicological methods - 1-10 p. digital
Publication Type: Journal Article
1056-8719
10.1016/j.vascn.2005.02.003 doi
Animals
Anti-Arrhythmia Agents--blood
Atrioventricular Node--surgery
Bundle of His--surgery
Cardiac Pacing, Artificial
Catheter Ablation
Cisapride--blood
Dogs
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical--methods
Electrocardiography--drug effects
Gastrointestinal Agents--blood
Histamine H1 Antagonists--blood
Ion Channels--antagonists & inhibitors
Long QT Syndrome--etiology
Male
Models, Animal
Models, Biological
Piperidines--blood
Pyridines--blood
Terfenadine--blood