Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration. [electronic resource]
Producer: 20100713Description: 841-54 p. digitalISSN:- 1573-904X
- Animals
- Behavior, Animal -- physiology
- Cells, Cultured
- DNA -- administration & dosage
- Gene Transfer Techniques
- Genetic Therapy -- methods
- Immunohistochemistry
- Injections, Spinal
- Interleukin-10 -- biosynthesis
- Lactic Acid
- Macrophages -- metabolism
- Male
- Nanoparticles
- Nitric Oxide -- metabolism
- Particle Size
- Peripheral Nervous System Diseases -- cerebrospinal fluid
- Plasmids -- genetics
- Polyglycolic Acid
- Polylactic Acid-Polyglycolic Acid Copolymer
- Rats
- Rats, Sprague-Dawley
- Reverse Transcriptase Polymerase Chain Reaction
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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