Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration.

Soderquist, Ryan Gene

Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration. [electronic resource] - Pharmaceutical research May 2010 - 841-54 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1573-904X

10.1007/s11095-010-0077-y doi


Animals
Behavior, Animal--physiology
Cells, Cultured
DNA--administration & dosage
Gene Transfer Techniques
Genetic Therapy--methods
Immunohistochemistry
Injections, Spinal
Interleukin-10--biosynthesis
Lactic Acid
Macrophages--metabolism
Male
Nanoparticles
Nitric Oxide--metabolism
Particle Size
Peripheral Nervous System Diseases--cerebrospinal fluid
Plasmids--genetics
Polyglycolic Acid
Polylactic Acid-Polyglycolic Acid Copolymer
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction