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  2. Details for: Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.
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Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation. [electronic resource]

By:
  • Stauffer, Shaun R
Contributor(s):
  • Stanton, Matthew G
  • Gregro, Alison R
  • Steinbeiser, Melissa A
  • Shaffer, Jennifer R
  • Nantermet, Philippe G
  • Barrow, James C
  • Rittle, Kenneth E
  • Collusi, Dennis
  • Espeseth, Amy S
  • Lai, Ming-Tain
  • Pietrak, Beth L
  • Holloway, M Katharine
  • McGaughey, Georgia B
  • Munshi, Sanjeev K
  • Hochman, Jerome H
  • Simon, Adam J
  • Selnick, Harold G
  • Graham, Samuel L
  • Vacca, Joseph P
Producer: 20070529Description: 1788-92 p. digitalISSN:
  • 0960-894X
Subject(s):
  • Amyloid Precursor Protein Secretases -- antagonists & inhibitors
  • Animals
  • Aspartic Acid Endopeptidases -- antagonists & inhibitors
  • Baculoviridae -- drug effects
  • Biological Availability
  • Cells, Cultured
  • Enzyme Inhibitors -- chemical synthesis
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Conformation
  • Molecular Weight
  • Niacinamide -- chemical synthesis
  • Rats
  • Structure-Activity Relationship
Online resources:
  • Available from publisher's website
In: Bioorganic & medicinal chemistry letters vol. 17
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Publication Type: Journal Article

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Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.

APA

Stauffer S. R., Stanton M. G., Gregro A. R., Steinbeiser M. A., Shaffer J. R., Nantermet P. G., Barrow J. C., Rittle K. E., Collusi D., Espeseth A. S., Lai M., Pietrak B. L., Holloway M. K., McGaughey G. B., Munshi S. K., Hochman J. H., Simon A. J., Selnick H. G., Graham S. L. & Vacca J. P. (20070529). Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation. : Bioorganic & medicinal chemistry letters.

Chicago

Stauffer Shaun R, Stanton Matthew G, Gregro Alison R, Steinbeiser Melissa A, Shaffer Jennifer R, Nantermet Philippe G, Barrow James C, Rittle Kenneth E, Collusi Dennis, Espeseth Amy S, Lai Ming-Tain, Pietrak Beth L, Holloway M Katharine, McGaughey Georgia B, Munshi Sanjeev K, Hochman Jerome H, Simon Adam J, Selnick Harold G, Graham Samuel L and Vacca Joseph P. 20070529. Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation. : Bioorganic & medicinal chemistry letters.

Harvard

Stauffer S. R., Stanton M. G., Gregro A. R., Steinbeiser M. A., Shaffer J. R., Nantermet P. G., Barrow J. C., Rittle K. E., Collusi D., Espeseth A. S., Lai M., Pietrak B. L., Holloway M. K., McGaughey G. B., Munshi S. K., Hochman J. H., Simon A. J., Selnick H. G., Graham S. L. and Vacca J. P. (20070529). Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation. : Bioorganic & medicinal chemistry letters.

MLA

Stauffer Shaun R, Stanton Matthew G, Gregro Alison R, Steinbeiser Melissa A, Shaffer Jennifer R, Nantermet Philippe G, Barrow James C, Rittle Kenneth E, Collusi Dennis, Espeseth Amy S, Lai Ming-Tain, Pietrak Beth L, Holloway M Katharine, McGaughey Georgia B, Munshi Sanjeev K, Hochman Jerome H, Simon Adam J, Selnick Harold G, Graham Samuel L and Vacca Joseph P. Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation. : Bioorganic & medicinal chemistry letters. 20070529.

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