MDM4 is a key therapeutic target in cutaneous melanoma. [electronic resource]
Producer: 20131022Description: 1239-47 p. digitalISSN:- 1546-170X
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Cycle Proteins
- Cell Line, Tumor -- metabolism
- Cell-Penetrating Peptides -- pharmacology
- Drug Resistance, Neoplasm -- drug effects
- Female
- GTP Phosphohydrolases -- genetics
- Gene Expression Regulation, Neoplastic
- Humans
- Keratinocytes -- metabolism
- Male
- Melanocytes -- metabolism
- Melanoma -- chemistry
- Melanoma, Experimental -- etiology
- Membrane Proteins -- genetics
- Mice
- Mice, Inbred C57BL
- Mice, Nude
- Mice, Transgenic
- Neoplasm Proteins -- antagonists & inhibitors
- Nuclear Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- Proto-Oncogene Proteins c-mdm2 -- biosynthesis
- Recombinant Fusion Proteins -- physiology
- Signal Transduction -- physiology
- Skin Neoplasms -- chemistry
- Tumor Stem Cell Assay
- Tumor Suppressor Protein p53 -- antagonists & inhibitors
- Up-Regulation
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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