MDM4 is a key therapeutic target in cutaneous melanoma.

Gembarska, Agnieszka

MDM4 is a key therapeutic target in cutaneous melanoma. [electronic resource] - Nature medicine Aug 2012 - 1239-47 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

1546-170X

10.1038/nm.2863 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle Proteins
Cell Line, Tumor--metabolism
Cell-Penetrating Peptides--pharmacology
Drug Resistance, Neoplasm--drug effects
Female
GTP Phosphohydrolases--genetics
Gene Expression Regulation, Neoplastic
Humans
Keratinocytes--metabolism
Male
Melanocytes--metabolism
Melanoma--chemistry
Melanoma, Experimental--etiology
Membrane Proteins--genetics
Mice
Mice, Inbred C57BL
Mice, Nude
Mice, Transgenic
Neoplasm Proteins--antagonists & inhibitors
Nuclear Proteins--antagonists & inhibitors
Proto-Oncogene Proteins--antagonists & inhibitors
Proto-Oncogene Proteins B-raf--antagonists & inhibitors
Proto-Oncogene Proteins c-mdm2--biosynthesis
Recombinant Fusion Proteins--physiology
Signal Transduction--physiology
Skin Neoplasms--chemistry
Tumor Stem Cell Assay
Tumor Suppressor Protein p53--antagonists & inhibitors
Up-Regulation
Xenograft Model Antitumor Assays