AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL. [electronic resource]
Producer: 20060301Description: 1618-32 p. digitalISSN:- 0969-7128
- Aminopeptidases
- Animals
- Brain -- metabolism
- Chlorocebus aethiops
- Dependovirus -- genetics
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
- Endopeptidases -- analysis
- Gene Expression
- Genes, Recessive
- Genetic Therapy -- methods
- Genetic Vectors -- administration & dosage
- Humans
- Immunoenzyme Techniques
- Male
- Microinjections
- Models, Animal
- Neuronal Ceroid-Lipofuscinoses -- metabolism
- Rats
- Rats, Inbred F344
- Serine Proteases
- Time Factors
- Tripeptidyl-Peptidase 1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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