Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis. [electronic resource]
Producer: 20141021Description: 5893-903 p. digitalISSN:- 1520-4804
- Acetamides -- chemical synthesis
- Crystallography, X-Ray
- Cyclic Nucleotide Phosphodiesterases, Type 4 -- metabolism
- Dermatitis, Atopic -- drug therapy
- Dose-Response Relationship, Drug
- Drug Discovery
- Humans
- Models, Molecular
- Molecular Structure
- Phosphodiesterase 4 Inhibitors -- chemical synthesis
- Pyridines -- chemical synthesis
- Structure-Activity Relationship
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Publication Type: Journal Article; Review
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