Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis. (Record no. 23971352)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01819 a2200481 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250516221851.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201410s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm500378a |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Felding, Jakob |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20141021 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Jul 2014 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 5893-903 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article; Review |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Acetamides |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Crystallography, X-Ray |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cyclic Nucleotide Phosphodiesterases, Type 4 |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dermatitis, Atopic |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dose-Response Relationship, Drug |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Discovery |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Molecular |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Structure |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Phosphodiesterase 4 Inhibitors |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyridines |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sørensen, Morten D |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Poulsen, Tina D |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Larsen, Jens |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Andersson, Christina |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Refer, Pia |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Engell, Karen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ladefoged, Lotte G |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Thormann, Thorsten |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vinggaard, Anne Marie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hegardt, Pontus |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Søhoel, Anders |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nielsen, Simon Feldbæk |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 57 |
| -- | no. 14 |
| -- | p. 5893-903 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm500378a">https://doi.org/10.1021/jm500378a</a> |
| Public note | Available from publisher's website |
No items available.