Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. [electronic resource]
Producer: 20080324Description: 1031-6 p. digitalISSN:- 1464-3405
- Alzheimer Disease -- drug therapy
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Animals
- Aspartic Acid -- analogs & derivatives
- Aspartic Acid Endopeptidases -- antagonists & inhibitors
- Cricetinae
- Cricetulus
- Crystallography, X-Ray
- Dipeptides -- chemical synthesis
- Drug Design
- Female
- Humans
- Mice
- Mice, Transgenic
- Models, Molecular
- Molecular Structure
- Structure-Activity Relationship
- Sulfonamides -- chemical synthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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