Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.
Ghosh, Arun K
Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. [electronic resource] - Bioorganic & medicinal chemistry letters Feb 2008 - 1031-6 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1464-3405
10.1016/j.bmcl.2007.12.028 doi
Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Animals
Aspartic Acid--analogs & derivatives
Aspartic Acid Endopeptidases--antagonists & inhibitors
Cricetinae
Cricetulus
Crystallography, X-Ray
Dipeptides--chemical synthesis
Drug Design
Female
Humans
Mice
Mice, Transgenic
Models, Molecular
Molecular Structure
Structure-Activity Relationship
Sulfonamides--chemical synthesis
Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. [electronic resource] - Bioorganic & medicinal chemistry letters Feb 2008 - 1031-6 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1464-3405
10.1016/j.bmcl.2007.12.028 doi
Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Animals
Aspartic Acid--analogs & derivatives
Aspartic Acid Endopeptidases--antagonists & inhibitors
Cricetinae
Cricetulus
Crystallography, X-Ray
Dipeptides--chemical synthesis
Drug Design
Female
Humans
Mice
Mice, Transgenic
Models, Molecular
Molecular Structure
Structure-Activity Relationship
Sulfonamides--chemical synthesis