Synthesis, resolution, and SAR of (+/-)-2-amino-N-methyl-alpha-(3-methyl-2-thienyl)benzeneethanamine++ + and related analogs as noncompetitive NMDA antagonists with neuroprotective properties. [electronic resource]
Producer: 19941027Description: 3008-15 p. digitalISSN:- 0022-2623
- Aniline Compounds -- chemical synthesis
- Animals
- Anti-Anxiety Agents -- chemical synthesis
- Anticonvulsants -- chemical synthesis
- Binding, Competitive
- Brain Ischemia -- prevention & control
- Cerebral Infarction -- prevention & control
- Crystallography, X-Ray
- Disease Models, Animal
- Gerbillinae
- Hippocampus -- blood supply
- Isomerism
- Male
- Mice
- Molecular Structure
- N-Methylaspartate -- antagonists & inhibitors
- Rats
- Rats, Sprague-Dawley
- Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors
- Structure-Activity Relationship
- Thiophenes -- chemical synthesis
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Publication Type: Journal Article
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