Synthesis, resolution, and SAR of (+/-)-2-amino-N-methyl-alpha-(3-methyl-2-thienyl)benzeneethanamine++ + and related analogs as noncompetitive NMDA antagonists with neuroprotective properties.

Martin, L L

Synthesis, resolution, and SAR of (+/-)-2-amino-N-methyl-alpha-(3-methyl-2-thienyl)benzeneethanamine++ + and related analogs as noncompetitive NMDA antagonists with neuroprotective properties. [electronic resource] - Journal of medicinal chemistry Sep 1994 - 3008-15 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm00045a004 doi


Aniline Compounds--chemical synthesis
Animals
Anti-Anxiety Agents--chemical synthesis
Anticonvulsants--chemical synthesis
Binding, Competitive
Brain Ischemia--prevention & control
Cerebral Infarction--prevention & control
Crystallography, X-Ray
Disease Models, Animal
Gerbillinae
Hippocampus--blood supply
Isomerism
Male
Mice
Molecular Structure
N-Methylaspartate--antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate--antagonists & inhibitors
Structure-Activity Relationship
Thiophenes--chemical synthesis