The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes. [electronic resource]
Producer: 20121116Description: 130-45 p. digitalISSN:- 2154-1272
- Animals
- Cell Line, Tumor
- Cell Nucleus -- metabolism
- Chromatin -- metabolism
- Epigenesis, Genetic
- Fluorescent Antibody Technique
- Glucuronidase -- genetics
- Histone Demethylases -- genetics
- Histones -- genetics
- Humans
- Methylation
- Mice
- Mice, Inbred C57BL
- RNA, Small Interfering -- genetics
- Real-Time Polymerase Chain Reaction
- T-Lymphocytes -- metabolism
- Transcriptional Activation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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