The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes.

He, Yi Qing

The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes. [electronic resource] - Transcription - 130-45 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2154-1272

10.4161/trns.19998 doi


Animals
Cell Line, Tumor
Cell Nucleus--metabolism
Chromatin--metabolism
Epigenesis, Genetic
Fluorescent Antibody Technique
Glucuronidase--genetics
Histone Demethylases--genetics
Histones--genetics
Humans
Methylation
Mice
Mice, Inbred C57BL
RNA, Small Interfering--genetics
Real-Time Polymerase Chain Reaction
T-Lymphocytes--metabolism
Transcriptional Activation