Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. [electronic resource]
Producer: 20110923Description: 4694-720 p. digitalISSN:- 1520-4804
- Administration, Oral
- Animals
- Antineoplastic Agents -- chemical synthesis
- Benzimidazoles -- chemical synthesis
- Biological Availability
- Cell Line, Tumor
- Dogs
- Drug Screening Assays, Antitumor
- Female
- Histone Deacetylase 1 -- antagonists & inhibitors
- Histone Deacetylase Inhibitors -- chemical synthesis
- Humans
- Isoenzymes -- antagonists & inhibitors
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Microsomes, Liver -- metabolism
- Neoplasm Transplantation
- Quantitative Structure-Activity Relationship
- Rats
- Rats, Wistar
- Stereoisomerism
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Publication Type: Journal Article
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