Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. (Record no. 20893638)

MARC details
000 -LEADER
fixed length control field 02488 a2200769 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250516041453.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 201109s 0 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1520-4804
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1021/jm2003552
Source of number or code doi
040 ## - CATALOGING SOURCE
Original cataloging agency NLM
Language of cataloging eng
Transcribing agency NLM
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Wang, Haishan
264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice 20110923
245 00 - TITLE STATEMENT
Title Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Medium [electronic resource]
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Journal of medicinal chemistry
Date of publication, distribution, etc. Jul 2011
300 ## - PHYSICAL DESCRIPTION
Extent 4694-720 p.
Other physical details digital
500 ## - GENERAL NOTE
General note Publication Type: Journal Article
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Administration, Oral
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Animals
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Antineoplastic Agents
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Benzimidazoles
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Biological Availability
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cell Line, Tumor
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Dogs
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Drug Screening Assays, Antitumor
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Histone Deacetylase 1
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Histone Deacetylase Inhibitors
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Isoenzymes
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Mice
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Mice, Inbred BALB C
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Mice, Nude
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Microsomes, Liver
General subdivision metabolism
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Neoplasm Transplantation
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Quantitative Structure-Activity Relationship
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rats
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rats, Wistar
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Stereoisomerism
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Yu, Niefang
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Chen, Dizhong
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lee, Ken Chi Lik
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lye, Pek Ling
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Chang, Joyce Wei Wei
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Deng, Weiping
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Ng, Melvin Chi Yeh
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lu, Ting
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Khoo, Mui Ling
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Poulsen, Anders
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sangthongpitag, Kanda
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Wu, Xiaofeng
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Hu, Changyong
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Goh, Kee Chuan
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Wang, Xukun
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Fang, Lijuan
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Goh, Kay Lin
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Khng, Hwee Hoon
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Goh, Siok Kun
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Yeo, Pauline
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Liu, Xin
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Bonday, Zahid
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Wood, Jeanette M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Dymock, Brian W
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kantharaj, Ethirajulu
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sun, Eric T
773 0# - HOST ITEM ENTRY
Title Journal of medicinal chemistry
Related parts vol. 54
-- no. 13
-- p. 4694-720
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.1021/jm2003552">https://doi.org/10.1021/jm2003552</a>
Public note Available from publisher's website

No items available.