Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. [electronic resource]
Producer: 20190527Description: 1945-1955 p. digitalISSN:- 2211-1247
- Amino Acid Sequence
- Animals
- Azaserine -- pharmacology
- Breast Neoplasms -- pathology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Female
- Fibroblasts -- drug effects
- Glutamine -- metabolism
- Mechanistic Target of Rapamycin Complex 1 -- metabolism
- Mice, Knockout
- Mice, Nude
- Nucleotides -- biosynthesis
- Promoter Regions, Genetic -- genetics
- Signal Transduction -- drug effects
- Sirtuin 3 -- deficiency
- Small Molecule Libraries -- pharmacology
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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