Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.
Gonzalez Herrera, Karina N
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. [electronic resource] - Cell reports 02 2018 - 1945-1955 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2211-1247
10.1016/j.celrep.2018.01.076 doi
Amino Acid Sequence
Animals
Azaserine--pharmacology
Breast Neoplasms--pathology
Cell Line, Tumor
Cell Proliferation--drug effects
Female
Fibroblasts--drug effects
Glutamine--metabolism
Mechanistic Target of Rapamycin Complex 1--metabolism
Mice, Knockout
Mice, Nude
Nucleotides--biosynthesis
Promoter Regions, Genetic--genetics
Signal Transduction--drug effects
Sirtuin 3--deficiency
Small Molecule Libraries--pharmacology
Up-Regulation--drug effects
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. [electronic resource] - Cell reports 02 2018 - 1945-1955 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2211-1247
10.1016/j.celrep.2018.01.076 doi
Amino Acid Sequence
Animals
Azaserine--pharmacology
Breast Neoplasms--pathology
Cell Line, Tumor
Cell Proliferation--drug effects
Female
Fibroblasts--drug effects
Glutamine--metabolism
Mechanistic Target of Rapamycin Complex 1--metabolism
Mice, Knockout
Mice, Nude
Nucleotides--biosynthesis
Promoter Regions, Genetic--genetics
Signal Transduction--drug effects
Sirtuin 3--deficiency
Small Molecule Libraries--pharmacology
Up-Regulation--drug effects