Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors. [electronic resource]
Producer: 20191125Description: 216 p. digitalISSN:- 1756-9966
- Aurora Kinase A -- genetics
- Benzamides -- pharmacology
- Cell Cycle Proteins -- genetics
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- Forkhead Box Protein M1 -- genetics
- Fusion Proteins, bcr-abl -- genetics
- Gene Expression Regulation, Neoplastic
- Humans
- Imatinib Mesylate -- pharmacology
- K562 Cells
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- genetics
- Phosphorylation
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- genetics
- Proto-Oncogene Proteins -- genetics
- Pteridines -- pharmacology
- Pyrazoles -- pharmacology
- Signal Transduction
- Thiostrepton -- pharmacology
- Up-Regulation
- Polo-Like Kinase 1
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Publication Type: Journal Article
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