Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors.

Mancini, M

Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors. [electronic resource] - Journal of experimental & clinical cancer research : CR May 2019 - 216 p. digital

Publication Type: Journal Article

1756-9966

10.1186/s13046-019-1197-9 doi


Aurora Kinase A--genetics
Benzamides--pharmacology
Cell Cycle Proteins--genetics
Cell Line, Tumor
Drug Resistance, Neoplasm
Forkhead Box Protein M1--genetics
Fusion Proteins, bcr-abl--genetics
Gene Expression Regulation, Neoplastic
Humans
Imatinib Mesylate--pharmacology
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--genetics
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Protein Serine-Threonine Kinases--genetics
Proto-Oncogene Proteins--genetics
Pteridines--pharmacology
Pyrazoles--pharmacology
Signal Transduction
Thiostrepton--pharmacology
Up-Regulation
Polo-Like Kinase 1