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A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. [electronic resource] by
- Zhang, Xu-Feng
- Shieh, Char-Chang
- Chapman, Mark L
- Matulenko, Mark A
- Hakeem, Ahmed H
- Atkinson, Robert N
- Kort, Michael E
- Marron, Brian E
- Joshi, Shailen
- Honore, Prisca
- Faltynek, Connie R
- Krafte, Douglas S
- Jarvis, Michael F
Producer: 20101014
In:
Neuropharmacology vol. 59
Availability: No items available.
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5.
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Discovery of a Series of Indazole TRPA1 Antagonists. [electronic resource] by
- Pryde, David C
- Marron, Brian E
- West, Christopher W
- Reister, Steven
- Amato, George
- Yoger, Katrina
- Antonio, Brett
- Padilla, Karen
- Cox, Peter J
- Turner, Jamie
- Warmus, Joseph S
- Swain, Nigel A
- Omoto, Kiyoyuki
- Mahoney, John H
- Gerlach, Aaron C
Publication details: ACS medicinal chemistry letters Jun 2017
In:
ACS medicinal chemistry letters vol. 8
Availability: No items available.
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6.
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High-throughput manual parallel synthesis using SynPhase crowns and lanterns. [electronic resource] by
- Gerritz, Samuel W
- Norman, Mark H
- Barger, Lee A
- Berman, Judd
- Bigham, Eric C
- Bishop, Michael J
- Drewry, David H
- Garrison, Deanna T
- Heyer, Dennis
- Hodson, Stephen J
- Kakel, Jennifer A
- Linn, James A
- Marron, Brian E
- Nanthakumar, Suganthini S
- Navas, Frank J
Producer: 20030513
In:
Journal of combinatorial chemistry vol. 5
Availability: No items available.
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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. [electronic resource] by
- McCormack, Ken
- Santos, Sonia
- Chapman, Mark L
- Krafte, Douglas S
- Marron, Brian E
- West, Christopher W
- Krambis, Michael J
- Antonio, Brett M
- Zellmer, Shannon G
- Printzenhoff, David
- Padilla, Karen M
- Lin, Zhixin
- Wagoner, P Kay
- Swain, Nigel A
- Stupple, Paul A
- de Groot, Marcel
- Butt, Richard P
- Castle, Neil A
Producer: 20130925
In:
Proceedings of the National Academy of Sciences of the United States of America vol. 110
Availability: No items available.
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8.
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Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D. [electronic resource] by
- Wakabayashi, Yuichi
- Telu, Sanjay
- Dick, Rachel M
- Fujita, Masahiro
- Ooms, Maarten
- Morse, Cheryl L
- Liow, Jeih-San
- Hong, Jinsoo S
- Gladding, Robert L
- Manly, Lester S
- Zoghbi, Sami S
- Mo, Xuesheng
- D'Amato, Emily C
- Sindac, Janice A
- Nugent, Richard A
- Marron, Brian E
- Gurney, Mark E
- Innis, Robert B
- Pike, Victor W
Producer: 20210618
In:
ACS chemical neuroscience vol. 11
Availability: No items available.
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9.
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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain. [electronic resource] by
- Scanio, Marc J C
- Shi, Lei
- Drizin, Irene
- Gregg, Robert J
- Atkinson, Robert N
- Thomas, James B
- Johnson, Matthew S
- Chapman, Mark L
- Liu, Dong
- Krambis, Michael J
- Liu, Yi
- Shieh, Char-Chang
- Zhang, Xufeng
- Simler, Gricelda H
- Joshi, Shailen
- Honore, Prisca
- Marsh, Kennan C
- Knox, Alison
- Werness, Stephen
- Antonio, Brett
- Krafte, Douglas S
- Jarvis, Michael F
- Faltynek, Connie R
- Marron, Brian E
- Kort, Michael E
Producer: 20110222
In:
Bioorganic & medicinal chemistry vol. 18
Availability: No items available.
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10.
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Highly potent and selective Na [electronic resource] by
- Storer, R Ian
- Pike, Andy
- Swain, Nigel A
- Alexandrou, Aristos J
- Bechle, Bruce M
- Blakemore, David C
- Brown, Alan D
- Castle, Neil A
- Corbett, Matthew S
- Flanagan, Neil J
- Fengas, David
- Johnson, M Scott
- Jones, Lyn H
- Marron, Brian E
- Payne, C Elizabeth
- Printzenhoff, David
- Rawson, David J
- Rose, Colin R
- Ryckmans, Thomas
- Sun, Jianmin
- Theile, Jonathan W
- Torella, Rubben
- Tseng, Elaine
- Warmus, Joseph S
Producer: 20171206
In:
Bioorganic & medicinal chemistry letters vol. 27
Availability: No items available.
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11.
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Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. [electronic resource] by
- Alexandrou, Aristos J
- Brown, Adam R
- Chapman, Mark L
- Estacion, Mark
- Turner, Jamie
- Mis, Malgorzata A
- Wilbrey, Anna
- Payne, Elizabeth C
- Gutteridge, Alex
- Cox, Peter J
- Doyle, Rachel
- Printzenhoff, David
- Lin, Zhixin
- Marron, Brian E
- West, Christopher
- Swain, Nigel A
- Storer, R Ian
- Stupple, Paul A
- Castle, Neil A
- Hounshell, James A
- Rivara, Mirko
- Randall, Andrew
- Dib-Hajj, Sulayman D
- Krafte, Douglas
- Waxman, Stephen G
- Patel, Manoj K
- Butt, Richard P
- Stevens, Edward B
Producer: 20160822
In:
PloS one vol. 11
Availability: No items available.
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12.
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Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain. [electronic resource] by
- Drizin, Irene
- Gregg, Robert J
- Scanio, Marc J C
- Shi, Lei
- Gross, Michael F
- Atkinson, Robert N
- Thomas, James B
- Johnson, Matthew S
- Carroll, William A
- Marron, Brian E
- Chapman, Mark L
- Liu, Dong
- Krambis, Michael J
- Shieh, Char-Chang
- Zhang, XuFeng
- Hernandez, Gricelda
- Gauvin, Donna M
- Mikusa, Joseph P
- Zhu, Chang Z
- Joshi, Shailen
- Honore, Prisca
- Marsh, Kennan C
- Roeloffs, Rosemarie
- Werness, Stephen
- Krafte, Douglas S
- Jarvis, Michael F
- Faltynek, Connie R
- Kort, Michael E
Producer: 20080715
In:
Bioorganic & medicinal chemistry vol. 16
Availability: No items available.
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13.
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Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. [electronic resource] by
- Kort, Michael E
- Atkinson, Robert N
- Thomas, James B
- Drizin, Irene
- Johnson, Matthew S
- Secrest, Matthew A
- Gregg, Robert J
- Scanio, Marc J C
- Shi, Lei
- Hakeem, Ahmed H
- Matulenko, Mark A
- Chapman, Mark L
- Krambis, Michael J
- Liu, Dong
- Shieh, Char-Chang
- Zhang, XuFeng
- Simler, Gricelda
- Mikusa, Joseph P
- Zhong, Chengmin
- Joshi, Shailen
- Honore, Prisca
- Roeloffs, Rosemarie
- Werness, Stephen
- Antonio, Brett
- Marsh, Kennan C
- Faltynek, Connie R
- Krafte, Douglas S
- Jarvis, Michael F
- Marron, Brian E
Producer: 20110329
In:
Bioorganic & medicinal chemistry letters vol. 20
Availability: No items available.
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14.
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Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. [electronic resource] by
- Kort, Michael E
- Drizin, Irene
- Gregg, Robert J
- Scanio, Marc J C
- Shi, Lei
- Gross, Michael F
- Atkinson, Robert N
- Johnson, Matthew S
- Pacofsky, Gregory J
- Thomas, James B
- Carroll, William A
- Krambis, Michael J
- Liu, Dong
- Shieh, Char-Chang
- Zhang, Xufeng
- Hernandez, Gricelda
- Mikusa, Joseph P
- Zhong, Chengmin
- Joshi, Shailen
- Honore, Prisca
- Roeloffs, Rosemarie
- Marsh, Kennan C
- Murray, Bernard P
- Liu, Jinrong
- Werness, Stephen
- Faltynek, Connie R
- Krafte, Douglas S
- Jarvis, Michael F
- Chapman, Mark L
- Marron, Brian E
Producer: 20080505
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
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15.
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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na [electronic resource] by
- Swain, Nigel A
- Batchelor, Dave
- Beaudoin, Serge
- Bechle, Bruce M
- Bradley, Paul A
- Brown, Alan D
- Brown, Bruce
- Butcher, Ken J
- Butt, Richard P
- Chapman, Mark L
- Denton, Stephen
- Ellis, David
- Galan, Sebastien R G
- Gaulier, Steven M
- Greener, Ben S
- de Groot, Marcel J
- Glossop, Mel S
- Gurrell, Ian K
- Hannam, Jo
- Johnson, Matthew S
- Lin, Zhixin
- Markworth, Christopher J
- Marron, Brian E
- Millan, David S
- Nakagawa, Shoko
- Pike, Andy
- Printzenhoff, David
- Rawson, David J
- Ransley, Sarah J
- Reister, Steven M
- Sasaki, Kosuke
- Storer, R Ian
- Stupple, Paul A
- West, Christopher W
Producer: 20170926
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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