A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. [electronic resource]
Producer: 20101014Description: 201-7 p. digitalISSN:- 1873-7064
- Animals
- Biophysics
- Cells, Cultured
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Electric Stimulation -- methods
- Ganglia, Spinal -- cytology
- Humans
- Hyperalgesia -- drug therapy
- Male
- Membrane Potentials -- drug effects
- Morpholines -- chemistry
- NAV1.8 Voltage-Gated Sodium Channel
- Neuralgia -- complications
- Niacinamide -- analogs & derivatives
- Pain Threshold -- drug effects
- Patch-Clamp Techniques -- methods
- Rats
- Rats, Sprague-Dawley
- Sensory Receptor Cells -- drug effects
- Sodium Channel Blockers -- chemistry
- Sodium Channels -- drug effects
- Spinal Cord Injuries -- complications
- Tetrodotoxin -- pharmacology
- Transfection -- methods
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Publication Type: Journal Article
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