A novel class of cardiotonic agents: synthesis and biological evaluation of pyridazino[4,5-b]indoles with cyclic AMP phosphodiesterases inhibiting properties. [electronic resource]
Producer: 19930928Description: 526-30 p. digitalISSN:- 0022-3549
- 3',5'-Cyclic-AMP Phosphodiesterases -- antagonists & inhibitors
- Animals
- Aorta, Thoracic -- drug effects
- Blood Platelets -- drug effects
- Cardiotonic Agents -- chemical synthesis
- Dogs
- Female
- Guinea Pigs
- Heart -- drug effects
- Humans
- In Vitro Techniques
- Indoles -- chemical synthesis
- Isoenzymes -- antagonists & inhibitors
- Male
- Myocardium -- enzymology
- Phosphodiesterase Inhibitors -- pharmacology
- Platelet Aggregation -- drug effects
- Platelet Aggregation Inhibitors -- chemical synthesis
- Pyridazines -- chemical synthesis
- Rats
- Rats, Wistar
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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