A novel class of cardiotonic agents: synthesis and biological evaluation of pyridazino[4,5-b]indoles with cyclic AMP phosphodiesterases inhibiting properties.

Monge, A

A novel class of cardiotonic agents: synthesis and biological evaluation of pyridazino[4,5-b]indoles with cyclic AMP phosphodiesterases inhibiting properties. [electronic resource] - Journal of pharmaceutical sciences May 1993 - 526-30 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3549

10.1002/jps.2600820519 doi


3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors
Animals
Aorta, Thoracic--drug effects
Blood Platelets--drug effects
Cardiotonic Agents--chemical synthesis
Dogs
Female
Guinea Pigs
Heart--drug effects
Humans
In Vitro Techniques
Indoles--chemical synthesis
Isoenzymes--antagonists & inhibitors
Male
Myocardium--enzymology
Phosphodiesterase Inhibitors--pharmacology
Platelet Aggregation--drug effects
Platelet Aggregation Inhibitors--chemical synthesis
Pyridazines--chemical synthesis
Rats
Rats, Wistar
Structure-Activity Relationship