A synthetic isoquinoline alkaloid, 1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), reduces inducible nitric oxide synthase expression and improves survival in a rodent model of endotoxic shock. [electronic resource]
Producer: 20020513Description: 561-7 p. digitalISSN:- 0022-3565
- Animals
- Aorta -- drug effects
- Cell Line
- DNA -- drug effects
- Disease Models, Animal
- Drug Interactions
- Fibrinolytic Agents -- chemical synthesis
- Gene Expression -- drug effects
- Isoquinolines -- chemical synthesis
- Lipopolysaccharides -- pharmacology
- Male
- Mice
- Mice, Inbred ICR
- NF-kappa B -- metabolism
- Nitrates -- blood
- Nitric Oxide -- metabolism
- Nitric Oxide Synthase -- genetics
- Nitric Oxide Synthase Type II
- Nitrites -- blood
- Promoter Regions, Genetic -- drug effects
- RNA, Messenger -- drug effects
- Rats
- Rats, Sprague-Dawley
- Shock, Septic -- blood
- Survival Rate
- Tetrahydroisoquinolines
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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