A synthetic isoquinoline alkaloid, 1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), reduces inducible nitric oxide synthase expression and improves survival in a rodent model of endotoxic shock.

Kang, Young Jin

A synthetic isoquinoline alkaloid, 1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), reduces inducible nitric oxide synthase expression and improves survival in a rodent model of endotoxic shock. [electronic resource] - The Journal of pharmacology and experimental therapeutics May 2002 - 561-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3565

10.1124/jpet.301.2.561 doi


Animals
Aorta--drug effects
Cell Line
DNA--drug effects
Disease Models, Animal
Drug Interactions
Fibrinolytic Agents--chemical synthesis
Gene Expression--drug effects
Isoquinolines--chemical synthesis
Lipopolysaccharides--pharmacology
Male
Mice
Mice, Inbred ICR
NF-kappa B--metabolism
Nitrates--blood
Nitric Oxide--metabolism
Nitric Oxide Synthase--genetics
Nitric Oxide Synthase Type II
Nitrites--blood
Promoter Regions, Genetic--drug effects
RNA, Messenger--drug effects
Rats
Rats, Sprague-Dawley
Shock, Septic--blood
Survival Rate
Tetrahydroisoquinolines