Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases. [electronic resource]
Producer: 20200629Description: 1401-1411 p. digitalISSN:- 1523-5866
- Animals
- Apoptosis
- Biomarkers, Tumor
- Brain Neoplasms -- drug therapy
- Breast Neoplasms -- drug therapy
- Cell Cycle
- Cell Proliferation
- Class I Phosphatidylinositol 3-Kinases -- antagonists & inhibitors
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Mice
- Mice, Nude
- Mutation
- Phosphatidylinositol 3-Kinases -- chemistry
- Piperazines -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Pyrimidines -- pharmacology
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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