Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases.
Ippen, Franziska Maria
Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases. [electronic resource] - Neuro-oncology 11 2019 - 1401-1411 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1523-5866
10.1093/neuonc/noz105 doi
Animals
Apoptosis
Biomarkers, Tumor
Brain Neoplasms--drug therapy
Breast Neoplasms--drug therapy
Cell Cycle
Cell Proliferation
Class I Phosphatidylinositol 3-Kinases--antagonists & inhibitors
Female
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Nude
Mutation
Phosphatidylinositol 3-Kinases--chemistry
Piperazines--pharmacology
Protein Kinase Inhibitors--pharmacology
Pyrimidines--pharmacology
TOR Serine-Threonine Kinases--antagonists & inhibitors
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases. [electronic resource] - Neuro-oncology 11 2019 - 1401-1411 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1523-5866
10.1093/neuonc/noz105 doi
Animals
Apoptosis
Biomarkers, Tumor
Brain Neoplasms--drug therapy
Breast Neoplasms--drug therapy
Cell Cycle
Cell Proliferation
Class I Phosphatidylinositol 3-Kinases--antagonists & inhibitors
Female
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Nude
Mutation
Phosphatidylinositol 3-Kinases--chemistry
Piperazines--pharmacology
Protein Kinase Inhibitors--pharmacology
Pyrimidines--pharmacology
TOR Serine-Threonine Kinases--antagonists & inhibitors
Tumor Cells, Cultured
Xenograft Model Antitumor Assays