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Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening. [electronic resource] by
- Koole, Cassandra
- Wootten, Denise
- Simms, John
- Valant, Celine
- Sridhar, Rohan
- Woodman, Owen L
- Miller, Laurence J
- Summers, Roger J
- Christopoulos, Arthur
- Sexton, Patrick M
Producer: 20100921
In:
Molecular pharmacology vol. 78
Availability: No items available.
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11.
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Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. [electronic resource] by
- Harikumar, Kaleeckal G
- Wootten, Denise
- Pinon, Delia I
- Koole, Cassandra
- Ball, Alicja M
- Furness, Sebastian G B
- Graham, Bim
- Dong, Maoqing
- Christopoulos, Arthur
- Miller, Laurence J
- Sexton, Patrick M
Producer: 20130117
In:
Proceedings of the National Academy of Sciences of the United States of America vol. 109
Availability: No items available.
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12.
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Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism. [electronic resource] by
- Lei, Saifei
- Clydesdale, Lachlan
- Dai, Antao
- Cai, Xiaoqing
- Feng, Yang
- Yang, Dehua
- Liang, Yi-Lynn
- Koole, Cassandra
- Zhao, Peishen
- Coudrat, Thomas
- Christopoulos, Arthur
- Wang, Ming-Wei
- Wootten, Denise
- Sexton, Patrick M
Producer: 20190122
In:
The Journal of biological chemistry vol. 293
Availability: No items available.
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13.
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A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures. [electronic resource] by
- Wootten, Denise
- Reynolds, Christopher A
- Koole, Cassandra
- Smith, Kevin J
- Mobarec, Juan C
- Simms, John
- Quon, Tezz
- Coudrat, Thomas
- Furness, Sebastian G B
- Miller, Laurence J
- Christopoulos, Arthur
- Sexton, Patrick M
Producer: 20160622
In:
Molecular pharmacology vol. 89
Availability: No items available.
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14.
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Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX. [electronic resource] by
- Sheykhzade, Majid
- Abdolalizadeh, Bahareh
- Koole, Cassandra
- Pickering, Darryl Scott
- Dreisig, Karin
- Johansson, Sara Ellinor
- Abboud, Balsam Kadri
- Dreier, Rasmus
- Berg, Jais Oliver
- Jeppesen, Jørgen Lykke
- Sexton, Patrick M
- Edvinsson, Lars
- Wootten, Denise
- Sams, Anette
Producer: 20181002
In:
European journal of pharmacology vol. 829
Availability: No items available.
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15.
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O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity. [electronic resource] by
- Levine, Paul M
- Balana, Aaron T
- Sturchler, Emmanuel
- Koole, Cassandra
- Noda, Hiroshi
- Zarzycka, Barbara
- Daley, Eileen J
- Truong, Tin T
- Katritch, Vsevolod
- Gardella, Thomas J
- Wootten, Denise
- Sexton, Patrick M
- McDonald, Patricia
- Pratt, Matthew R
Producer: 20200923
In:
Journal of the American Chemical Society vol. 141
Availability: No items available.
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16.
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Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation. [electronic resource] by
- Liang, Yi-Lynn
- Belousoff, Matthew J
- Zhao, Peishen
- Koole, Cassandra
- Fletcher, Madeleine M
- Truong, Tin T
- Julita, Villy
- Christopoulos, George
- Xu, H Eric
- Zhang, Yan
- Khoshouei, Maryam
- Christopoulos, Arthur
- Danev, Radostin
- Sexton, Patrick M
- Wootten, Denise
Producer: 20200427
In:
Molecular cell vol. 77
Availability: No items available.
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17.
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Cryo-EM structure of the active, G [electronic resource] by
- Liang, Yi-Lynn
- Khoshouei, Maryam
- Deganutti, Giuseppe
- Glukhova, Alisa
- Koole, Cassandra
- Peat, Thomas S
- Radjainia, Mazdak
- Plitzko, Jürgen M
- Baumeister, Wolfgang
- Miller, Laurence J
- Hay, Deborah L
- Christopoulos, Arthur
- Reynolds, Christopher A
- Wootten, Denise
- Sexton, Patrick M
Producer: 20190318
In:
Nature vol. 561
Availability: No items available.
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18.
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Structure and Dynamics of Adrenomedullin Receptors AM [electronic resource] by
- Liang, Yi-Lynn
- Belousoff, Matthew J
- Fletcher, Madeleine M
- Zhang, Xin
- Khoshouei, Maryam
- Deganutti, Giuseppe
- Koole, Cassandra
- Furness, Sebastian G B
- Miller, Laurence J
- Hay, Debbie L
- Christopoulos, Arthur
- Reynolds, Christopher A
- Danev, Radostin
- Wootten, Denise
- Sexton, Patrick M
Publication details: ACS pharmacology & translational science Apr 2020
In:
ACS pharmacology & translational science vol. 3
Availability: No items available.
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19.
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The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism. [electronic resource] by
- Wootten, Denise
- Reynolds, Christopher A
- Smith, Kevin J
- Mobarec, Juan C
- Koole, Cassandra
- Savage, Emilia E
- Pabreja, Kavita
- Simms, John
- Sridhar, Rohan
- Furness, Sebastian G B
- Liu, Mengjie
- Thompson, Philip E
- Miller, Laurence J
- Christopoulos, Arthur
- Sexton, Patrick M
Producer: 20170110
In:
Cell vol. 165
Availability: No items available.
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20.
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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. [electronic resource] by
- Liang, Yi-Lynn
- Khoshouei, Maryam
- Glukhova, Alisa
- Furness, Sebastian G B
- Zhao, Peishen
- Clydesdale, Lachlan
- Koole, Cassandra
- Truong, Tin T
- Thal, David M
- Lei, Saifei
- Radjainia, Mazdak
- Danev, Radostin
- Baumeister, Wolfgang
- Wang, Ming-Wei
- Miller, Laurence J
- Christopoulos, Arthur
- Sexton, Patrick M
- Wootten, Denise
Producer: 20180717
In:
Nature vol. 555
Availability: No items available.
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