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Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity. [electronic resource] by
- Tebben, Andrew J
- Ruzanov, Maxim
- Gao, Mian
- Xie, Dianlin
- Kiefer, Susan E
- Yan, Chunhong
- Newitt, John A
- Zhang, Liping
- Kim, Kyoung
- Lu, Hao
- Kopcho, Lisa M
- Sheriff, Steven
Producer: 20171031
In:
Acta crystallographica. Section D, Structural biology vol. 72
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6.
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The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. [electronic resource] by
- Kiefer, Susan E
- Chang, Chiehying J
- Kimura, S Roy
- Gao, Mian
- Xie, Dianlin
- Zhang, Yaqun
- Zhang, Guifen
- Gill, Martin B
- Mastalerz, Harold
- Thompson, Lorin A
- Cacace, Angela M
- Sheriff, Steven
Producer: 20141114
In:
Acta crystallographica. Section F, Structural biology communications vol. 70
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Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms. [electronic resource] by
- Kish, Kevin
- McDonnell, Patricia A
- Goldfarb, Valentina
- Gao, Mian
- Metzler, William J
- Langley, David R
- Bryson, James W
- Kiefer, Susan E
- Carpenter, Brian
- Kostich, Walter A
- Westphal, Ryan S
- Sheriff, Steven
Producer: 20111021
In:
Acta crystallographica. Section F, Structural biology and crystallization communications vol. 67
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Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects. [electronic resource] by
- Constantine, Keith L
- Mueller, Luciano
- Metzler, William J
- McDonnell, Patricia A
- Todderud, Gordon
- Goldfarb, Valentina
- Fan, Yi
- Newitt, John A
- Kiefer, Susan E
- Gao, Mian
- Tortolani, David
- Vaccaro, Wayne
- Tokarski, John
Producer: 20081030
In:
Journal of medicinal chemistry vol. 51
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The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. [electronic resource] by
- Tokarski, John S
- Newitt, John A
- Chang, Chieh Ying J
- Cheng, Janet D
- Wittekind, Michael
- Kiefer, Susan E
- Kish, Kevin
- Lee, Francis Y F
- Borzillerri, Robert
- Lombardo, Louis J
- Xie, Dianlin
- Zhang, Yaqun
- Klei, Herbert E
Producer: 20060727
In:
Cancer research vol. 66
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Benzothiazole based inhibitors of p38alpha MAP kinase. [electronic resource] by
- Liu, Chunjian
- Lin, James
- Pitt, Sidney
- Zhang, Rosemary F
- Sack, John S
- Kiefer, Susan E
- Kish, Kevin
- Doweyko, Arthur M
- Zhang, Hongjian
- Marathe, Punit H
- Trzaskos, James
- Mckinnon, Murray
- Dodd, John H
- Barrish, Joel C
- Schieven, Gary L
- Leftheris, Katerina
Producer: 20080609
In:
Bioorganic & medicinal chemistry letters vol. 18
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Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors. [electronic resource] by
- Das, Jagabandhu
- Moquin, Robert V
- Pitt, Sidney
- Zhang, Rosemary
- Shen, Ding Ren
- McIntyre, Kim W
- Gillooly, Kathleen
- Doweyko, Arthur M
- Sack, John S
- Zhang, Hongjian
- Kiefer, Susan E
- Kish, Kevin
- McKinnon, Murray
- Barrish, Joel C
- Dodd, John H
- Schieven, Gary L
- Leftheris, Katerina
Producer: 20080516
In:
Bioorganic & medicinal chemistry letters vol. 18
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Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors. [electronic resource] by
- Lin, Shuqun
- Wrobleski, Stephen T
- Hynes, John
- Pitt, Sidney
- Zhang, Rosemary
- Fan, Yi
- Doweyko, Arthur M
- Kish, Kevin F
- Sack, John S
- Malley, Mary F
- Kiefer, Susan E
- Newitt, John A
- McKinnon, Murray
- Trzaskos, James
- Barrish, Joel C
- Dodd, John H
- Schieven, Gary L
- Leftheris, Katerina
Producer: 20110224
In:
Bioorganic & medicinal chemistry letters vol. 20
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13.
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Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop. [electronic resource] by
- Sheriff, Steven
- Beno, Brett R
- Zhai, Weixu
- Kostich, Walter A
- McDonnell, Patricia A
- Kish, Kevin
- Goldfarb, Valentina
- Gao, Mian
- Kiefer, Susan E
- Yanchunas, Joseph
- Huang, Yanling
- Shi, Shuhao
- Zhu, Shirong
- Dzierba, Carolyn
- Bronson, Joanne
- Macor, John E
- Appiah, Kingsley K
- Westphal, Ryan S
- O'Connell, Jonathan
- Gerritz, Samuel W
Producer: 20111212
In:
Journal of medicinal chemistry vol. 54
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14.
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Assessing compound binding to the Eg5 motor domain using a thermal shift assay. [electronic resource] by
- McDonnell, Patricia A
- Yanchunas, Joseph
- Newitt, John A
- Tao, Li
- Kiefer, Susan E
- Ortega, Marie
- Kut, Stephanie
- Burford, Neil
- Goldfarb, Valentina
- Duke, Gerald J
- Shen, Henry
- Metzler, William
- Doyle, Michael
- Chen, Zhong
- Tarby, Christine
- Borzilleri, Robert
- Vaccaro, Wayne
- Gottardis, Marco
- Lu, Songfeng
- Crews, Donald
- Kim, Kyoung
- Lombardo, Louis
- Roussell, Deborah L
Producer: 20090917
In:
Analytical biochemistry vol. 392
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5-amino-pyrazoles as potent and selective p38α inhibitors. [electronic resource] by
- Das, Jagabandhu
- Moquin, Robert V
- Dyckman, Alaric J
- Li, Tianle
- Pitt, Sidney
- Zhang, Rosemary
- Shen, Ding Ren
- McIntyre, Kim W
- Gillooly, Kathleen
- Doweyko, Arthur M
- Newitt, John A
- Sack, John S
- Zhang, Hongjian
- Kiefer, Susan E
- Kish, Kevin
- McKinnon, Murray
- Barrish, Joel C
- Dodd, John H
- Schieven, Gary L
- Leftheris, Katerina
Producer: 20110223
In:
Bioorganic & medicinal chemistry letters vol. 20
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16.
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Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors. [electronic resource] by
- Dyckman, Alaric J
- Li, Tianle
- Pitt, Sidney
- Zhang, Rosemary
- Shen, Ding Ren
- McIntyre, Kim W
- Gillooly, Kathleen M
- Shuster, David J
- Doweyko, Arthur M
- Sack, John S
- Kish, Kevin
- Kiefer, Susan E
- Newitt, John A
- Zhang, Hongjian
- Marathe, Punit H
- McKinnon, Murray
- Barrish, Joel C
- Dodd, John H
- Schieven, Gary L
- Leftheris, Katerina
Producer: 20111122
In:
Bioorganic & medicinal chemistry letters vol. 21
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17.
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The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode. [electronic resource] by
- Wrobleski, Stephen T
- Lin, Shuqun
- Dhar, T G Murali
- Dyckman, Alaric J
- Li, Tianle
- Pitt, Sidney
- Zhang, Rosemary
- Fan, Yi
- Doweyko, Arthur M
- Tokarski, John S
- Kish, Kevin F
- Kiefer, Susan E
- Sack, John S
- Newitt, John A
- Witmer, Mark R
- McKinnon, Murray
- Barrish, Joel C
- Dodd, John H
- Schieven, Gary L
- Leftheris, Katerina
Producer: 20140121
In:
Bioorganic & medicinal chemistry letters vol. 23
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18.
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The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor. [electronic resource] by
- Hynes, John
- Wu, Hong
- Pitt, Sidney
- Shen, Ding Ren
- Zhang, Rosemary
- Schieven, Gary L
- Gillooly, Kathleen M
- Shuster, David J
- Taylor, Tracy L
- Yang, XiaoXia
- McIntyre, Kim W
- McKinnon, Murray
- Zhang, Hongjian
- Marathe, Punit H
- Doweyko, Arthur M
- Kish, Kevin
- Kiefer, Susan E
- Sack, John S
- Newitt, John A
- Barrish, Joel C
- Dodd, John
- Leftheris, Katerina
Producer: 20080609
In:
Bioorganic & medicinal chemistry letters vol. 18
Availability: No items available.
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19.
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Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors. [electronic resource] by
- Hynes, John
- Dyckman, Alaric J
- Lin, Shuqun
- Wrobleski, Stephen T
- Wu, Hong
- Gillooly, Kathleen M
- Kanner, Steven B
- Lonial, Herinder
- Loo, Derek
- McIntyre, Kim W
- Pitt, Sidney
- Shen, Ding Ren
- Shuster, David J
- Yang, Xiaoxia
- Zhang, Rosemary
- Behnia, Kamelia
- Zhang, Hongjian
- Marathe, Punit H
- Doweyko, Arthur M
- Tokarski, John S
- Sack, John S
- Pokross, Matthew
- Kiefer, Susan E
- Newitt, John A
- Barrish, Joel C
- Dodd, John
- Schieven, Gary L
- Leftheris, Katerina
Producer: 20080227
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
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20.
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Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases. [electronic resource] by
- Liu, Chunjian
- Lin, James
- Wrobleski, Stephen T
- Lin, Shuqun
- Hynes, John
- Wu, Hong
- Dyckman, Alaric J
- Li, Tianle
- Wityak, John
- Gillooly, Kathleen M
- Pitt, Sidney
- Shen, Ding Ren
- Zhang, Rosemary F
- McIntyre, Kim W
- Salter-Cid, Luisa
- Shuster, David J
- Zhang, Hongjian
- Marathe, Punit H
- Doweyko, Arthur M
- Sack, John S
- Kiefer, Susan E
- Kish, Kevin F
- Newitt, John A
- McKinnon, Murray
- Dodd, John H
- Barrish, Joel C
- Schieven, Gary L
- Leftheris, Katerina
Producer: 20101011
In:
Journal of medicinal chemistry vol. 53
Availability: No items available.
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