The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. [electronic resource]
Producer: 20060727Description: 5790-7 p. digitalISSN:- 0008-5472
- Animals
- Benzamides
- Crystallography, X-Ray
- Dasatinib
- Drug Resistance, Neoplasm
- Enzyme Activation
- Humans
- Imatinib Mesylate
- Models, Molecular
- Piperazines -- chemistry
- Protein Conformation
- Protein Kinase Inhibitors -- chemistry
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-abl -- antagonists & inhibitors
- Pyrimidines -- chemistry
- Structure-Activity Relationship
- Thiazoles -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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