Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest. [electronic resource]
Producer: 20140902Description: 249-58 p. digitalISSN:- 1096-0333
- Antineoplastic Agents, Alkylating -- agonists
- Apoptosis -- drug effects
- Autophagy -- drug effects
- Autophagy-Related Protein 7
- Carbamates -- agonists
- Carcinoma -- drug therapy
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Checkpoint Kinase 1
- Class III Phosphatidylinositol 3-Kinases -- antagonists & inhibitors
- Cross-Linking Reagents -- pharmacology
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Female
- Gene Silencing
- HeLa Cells
- Heterocyclic Compounds, 3-Ring -- agonists
- Humans
- Indenes -- agonists
- Neoplasm Proteins -- antagonists & inhibitors
- Phosphorylation -- drug effects
- Protein Kinases -- chemistry
- Protein Processing, Post-Translational -- drug effects
- S Phase -- drug effects
- Ubiquitin-Activating Enzymes -- antagonists & inhibitors
- Vacuolar Proton-Translocating ATPases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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