Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest.

Liou, Jong-Shian

Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest. [electronic resource] - Toxicology and applied pharmacology Aug 2014 - 249-58 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-0333

10.1016/j.taap.2014.04.028 doi


Antineoplastic Agents, Alkylating--agonists
Apoptosis--drug effects
Autophagy--drug effects
Autophagy-Related Protein 7
Carbamates--agonists
Carcinoma--drug therapy
Cell Proliferation--drug effects
Cell Survival--drug effects
Checkpoint Kinase 1
Class III Phosphatidylinositol 3-Kinases--antagonists & inhibitors
Cross-Linking Reagents--pharmacology
Drug Synergism
Enzyme Inhibitors--pharmacology
Female
Gene Silencing
HeLa Cells
Heterocyclic Compounds, 3-Ring--agonists
Humans
Indenes--agonists
Neoplasm Proteins--antagonists & inhibitors
Phosphorylation--drug effects
Protein Kinases--chemistry
Protein Processing, Post-Translational--drug effects
S Phase--drug effects
Ubiquitin-Activating Enzymes--antagonists & inhibitors
Vacuolar Proton-Translocating ATPases--antagonists & inhibitors