Administration of two macrophage-derived interferon-gamma-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-gamma. [electronic resource]
Producer: 20030115Description: 31-42 p. digitalISSN:- 0008-8749
- Acute-Phase Proteins -- analysis
- Animals
- Apoptosis
- CD3 Complex
- Cytokines -- blood
- DNA-Binding Proteins -- deficiency
- Dose-Response Relationship, Drug
- Female
- Interferon-gamma -- deficiency
- Interleukin-12 -- antagonists & inhibitors
- Interleukin-15 -- antagonists & inhibitors
- Intestinal Mucosa -- pathology
- Killer Cells, Natural -- immunology
- Macrophages -- immunology
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, SCID
- Mice, Transgenic
- Receptors, Antigen, T-Cell -- genetics
- Receptors, Tumor Necrosis Factor -- deficiency
- STAT1 Transcription Factor
- STAT4 Transcription Factor
- Shock -- blood
- Time Factors
- Trans-Activators -- deficiency
No physical items for this record
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
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