Administration of two macrophage-derived interferon-gamma-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-gamma.

Biber, Jennifer L

Administration of two macrophage-derived interferon-gamma-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-gamma. [electronic resource] - Cellular immunology - 31-42 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

0008-8749

10.1016/s0008-8749(02)00501-4 doi


Acute-Phase Proteins--analysis
Animals
Apoptosis
CD3 Complex
Cytokines--blood
DNA-Binding Proteins--deficiency
Dose-Response Relationship, Drug
Female
Interferon-gamma--deficiency
Interleukin-12--antagonists & inhibitors
Interleukin-15--antagonists & inhibitors
Intestinal Mucosa--pathology
Killer Cells, Natural--immunology
Macrophages--immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Mice, SCID
Mice, Transgenic
Receptors, Antigen, T-Cell--genetics
Receptors, Tumor Necrosis Factor--deficiency
STAT1 Transcription Factor
STAT4 Transcription Factor
Shock--blood
Time Factors
Trans-Activators--deficiency