DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. [electronic resource]
Producer: 20030903Description: 6914-27 p. digitalISSN:- 1529-2401
- Alzheimer Disease -- genetics
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Apoptosis -- genetics
- Bromodeoxyuridine
- Cell Cycle -- drug effects
- Cells, Cultured
- DNA -- biosynthesis
- Genes, Dominant
- Genetic Vectors -- genetics
- In Situ Nick-End Labeling
- Mutation
- Nervous System -- metabolism
- Neurons -- cytology
- Organ Specificity
- Protein Serine-Threonine Kinases -- genetics
- RNA, Messenger -- biosynthesis
- Rats
- Recombinant Fusion Proteins -- genetics
- Sequence Deletion -- genetics
- Signal Transduction -- physiology
- p21-Activated Kinases
- rab GTP-Binding Proteins -- biosynthesis
- rab5 GTP-Binding Proteins -- biosynthesis
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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