DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.

McPhie, Donna L

DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Jul 2003 - 6914-27 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

1529-2401


Alzheimer Disease--genetics
Amyloid beta-Protein Precursor--genetics
Animals
Apoptosis--genetics
Bromodeoxyuridine
Cell Cycle--drug effects
Cells, Cultured
DNA--biosynthesis
Genes, Dominant
Genetic Vectors--genetics
In Situ Nick-End Labeling
Mutation
Nervous System--metabolism
Neurons--cytology
Organ Specificity
Protein Serine-Threonine Kinases--genetics
RNA, Messenger--biosynthesis
Rats
Recombinant Fusion Proteins--genetics
Sequence Deletion--genetics
Signal Transduction--physiology
p21-Activated Kinases
rab GTP-Binding Proteins--biosynthesis
rab5 GTP-Binding Proteins--biosynthesis