Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. [electronic resource]
Producer: 20051108Description: 31537-47 p. digitalISSN:- 0021-9258
- Amyloid Precursor Protein Secretases
- Aspartic Acid Endopeptidases -- physiology
- Cell Line
- Endopeptidases
- Enzyme Activation -- genetics
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Gene Deletion
- Humans
- Membrane Proteins -- deficiency
- Phosphatidylinositol 3-Kinases -- metabolism
- Platelet-Derived Growth Factor -- physiology
- Presenilin-1
- Presenilin-2
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Signal Transduction -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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