A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies. [electronic resource]
Producer: 20140715Description: 2434-40 p. digitalISSN:- 1532-1827
- Adult
- Aged
- Antineoplastic Agents -- administration & dosage
- Cell Cycle Proteins -- antagonists & inhibitors
- Combined Modality Therapy
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Half-Life
- Hematologic Diseases -- chemically induced
- Humans
- Infusions, Intravenous
- Male
- Maximum Tolerated Dose
- Middle Aged
- Neoplasm Proteins -- antagonists & inhibitors
- Neoplasms -- drug therapy
- Protein Kinase Inhibitors -- administration & dosage
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Pteridines -- administration & dosage
- Salvage Therapy
- Taiwan
- Treatment Outcome
- Polo-Like Kinase 1
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Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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