A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies.

Lin, C-C

A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies. [electronic resource] - British journal of cancer May 2014 - 2434-40 p. digital

Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1532-1827

10.1038/bjc.2014.195 doi


Adult
Aged
Antineoplastic Agents--administration & dosage
Cell Cycle Proteins--antagonists & inhibitors
Combined Modality Therapy
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Half-Life
Hematologic Diseases--chemically induced
Humans
Infusions, Intravenous
Male
Maximum Tolerated Dose
Middle Aged
Neoplasm Proteins--antagonists & inhibitors
Neoplasms--drug therapy
Protein Kinase Inhibitors--administration & dosage
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins--antagonists & inhibitors
Pteridines--administration & dosage
Salvage Therapy
Taiwan
Treatment Outcome
Polo-Like Kinase 1