A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. [electronic resource]
Producer: 20031002Description: 32861-71 p. digitalISSN:- 0021-9258
- Active Transport, Cell Nucleus
- Adenosine Triphosphate -- metabolism
- Animals
- Blotting, Western
- Cell Adhesion
- Cell Line
- Cell Nucleus -- metabolism
- Cells, Cultured
- Dimerization
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- Enzyme-Linked Immunosorbent Assay
- Fibroblasts -- metabolism
- Gene Expression Regulation
- Genes, Reporter
- Genetic Vectors
- Glutathione Transferase -- metabolism
- Humans
- Hydrolysis
- I-kappa B Kinase
- Inflammation
- Inhibitory Concentration 50
- Interleukin-1 -- metabolism
- Kinetics
- Lipopolysaccharides -- pharmacology
- Models, Chemical
- NF-kappa B -- metabolism
- Phosphoric Monoester Hydrolases -- metabolism
- Phosphorylation
- Precipitin Tests
- Protein Binding
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Protein Transport
- Rats
- Rats, Wistar
- Recombinant Proteins -- metabolism
- Signal Transduction
- Synovial Membrane -- immunology
- Thiophenes -- pharmacology
- Time Factors
- Transcription Factor RelA
- Transcription, Genetic
- Transcriptional Activation
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Publication Type: Journal Article
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