A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts.

Kishore, Nandini

A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. [electronic resource] - The Journal of biological chemistry Aug 2003 - 32861-71 p. digital

Publication Type: Journal Article

0021-9258

10.1074/jbc.M211439200 doi


Active Transport, Cell Nucleus
Adenosine Triphosphate--metabolism
Animals
Blotting, Western
Cell Adhesion
Cell Line
Cell Nucleus--metabolism
Cells, Cultured
Dimerization
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacology
Enzyme-Linked Immunosorbent Assay
Fibroblasts--metabolism
Gene Expression Regulation
Genes, Reporter
Genetic Vectors
Glutathione Transferase--metabolism
Humans
Hydrolysis
I-kappa B Kinase
Inflammation
Inhibitory Concentration 50
Interleukin-1--metabolism
Kinetics
Lipopolysaccharides--pharmacology
Models, Chemical
NF-kappa B--metabolism
Phosphoric Monoester Hydrolases--metabolism
Phosphorylation
Precipitin Tests
Protein Binding
Protein Serine-Threonine Kinases--antagonists & inhibitors
Protein Transport
Rats
Rats, Wistar
Recombinant Proteins--metabolism
Signal Transduction
Synovial Membrane--immunology
Thiophenes--pharmacology
Time Factors
Transcription Factor RelA
Transcription, Genetic
Transcriptional Activation