Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2). [electronic resource]
Producer: 20030204Description: 49-63 p. digitalISSN:- 0022-2623
- Administration, Oral
- Aminoquinolines
- Aniline Compounds
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Division -- drug effects
- Enzyme Inhibitors -- chemical synthesis
- ErbB Receptors -- antagonists & inhibitors
- Glutathione -- antagonists & inhibitors
- Humans
- Mice
- Models, Molecular
- Organic Chemicals
- Phosphorylation
- Receptor, ErbB-2 -- antagonists & inhibitors
- Structure-Activity Relationship
- Substrate Specificity
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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