Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2). (Record no. 12305888)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02278 a2200637 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250514054104.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200302s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0022-2623 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm020241c |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Wissner, Allan |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20030204 |
| 245 00 - TITLE STATEMENT | |
| Title | Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2). |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Jan 2003 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 49-63 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Administration, Oral |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Aminoquinolines |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Aniline Compounds |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antineoplastic Agents |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Division |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Enzyme Inhibitors |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ErbB Receptors |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Glutathione |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Molecular |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Organic Chemicals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Phosphorylation |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Receptor, ErbB-2 |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Substrate Specificity |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Tumor Cells, Cultured |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Xenograft Model Antitumor Assays |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Overbeek, Elsebe |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reich, Marvin F |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Floyd, M Brawner |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Johnson, Bernard D |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mamuya, Nellie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rosfjord, Edward C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Discafani, Carolyn |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Davis, Rachel |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shi, Xiaoqing |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rabindran, Sridhar K |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gruber, Brian C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ye, Fei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hallett, William A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nilakantan, Ramaswamy |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shen, Ru |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Yu-Fen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Greenberger, Lee M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tsou, Hwei-Ru |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 46 |
| -- | no. 1 |
| -- | p. 49-63 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm020241c">https://doi.org/10.1021/jm020241c</a> |
| Public note | Available from publisher's website |
No items available.