Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line. [electronic resource]
Producer: 20131022Description: 405-10 p. digitalISSN:- 1347-5223
- Binding Sites
- Catalytic Domain
- Cell Proliferation -- drug effects
- Cyclic GMP -- metabolism
- Cyclic Nucleotide Phosphodiesterases, Type 3 -- chemistry
- Cyclization
- HT29 Cells
- Humans
- Hydrolysis
- Molecular Docking Simulation
- Phosphodiesterase 3 Inhibitors -- chemistry
- Protein Binding
- Pyridines -- chemistry
- Pyrimidines -- chemistry
- Structure-Activity Relationship
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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