Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.

Abadi, Ashraf Hassan

Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line. [electronic resource] - Chemical & pharmaceutical bulletin 2013 - 405-10 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1347-5223

10.1248/cpb.c12-00993 doi


Binding Sites
Catalytic Domain
Cell Proliferation--drug effects
Cyclic GMP--metabolism
Cyclic Nucleotide Phosphodiesterases, Type 3--chemistry
Cyclization
HT29 Cells
Humans
Hydrolysis
Molecular Docking Simulation
Phosphodiesterase 3 Inhibitors--chemistry
Protein Binding
Pyridines--chemistry
Pyrimidines--chemistry
Structure-Activity Relationship
Substrate Specificity