Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. [electronic resource]
Producer: 20120305Description: 1709-20 p. digitalISSN:- 1097-4652
- ATP Citrate (pro-S)-Lyase -- antagonists & inhibitors
- Animals
- Apoptosis
- Cell Cycle
- Cell Line, Tumor
- Cell Proliferation
- Combined Modality Therapy
- Epithelial-Mesenchymal Transition
- ErbB Receptors -- genetics
- Female
- Gene Knockdown Techniques
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use
- Lung Neoplasms -- drug therapy
- MAP Kinase Signaling System -- drug effects
- Mice
- Mutation
- Phosphoinositide-3 Kinase Inhibitors
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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