Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.

Hanai, Jun-ichi

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. [electronic resource] - Journal of cellular physiology Apr 2012 - 1709-20 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1097-4652

10.1002/jcp.22895 doi


ATP Citrate (pro-S)-Lyase--antagonists & inhibitors
Animals
Apoptosis
Cell Cycle
Cell Line, Tumor
Cell Proliferation
Combined Modality Therapy
Epithelial-Mesenchymal Transition
ErbB Receptors--genetics
Female
Gene Knockdown Techniques
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--therapeutic use
Lung Neoplasms--drug therapy
MAP Kinase Signaling System--drug effects
Mice
Mutation
Phosphoinositide-3 Kinase Inhibitors
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Signal Transduction--drug effects
Xenograft Model Antitumor Assays