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Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists. [electronic resource] by
- Taylor, Simon J
- Demont, Emmanuel H
- Gray, James
- Deeks, Nigel
- Patel, Aarti
- Nguyen, Dung
- Taylor, Maxine
- Hood, Steve
- Watson, Robert J
- Bit, Rino A
- McClure, Fiona
- Ashall, Holly
- Witherington, Jason
Producer: 20160202
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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3.
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Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis. [electronic resource] by
- Snoek, Susanne A
- Verstege, Marleen I
- van der Zanden, Esmerij P
- Deeks, Nigel
- Bulmer, David C
- Skynner, Michael
- Lee, Kevin
- Te Velde, Anje A
- Boeckxstaens, Guy E
- de Jonge, Wouter J
Producer: 20100602
In:
British journal of pharmacology vol. 160
Availability: No items available.
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4.
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The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists. [electronic resource] by
- Taylor, Simon
- Gray, James R J
- Willis, Robert
- Deeks, Nigel
- Haynes, Andrea
- Campbell, Colin
- Gaskin, Pam
- Leavens, Karen
- Demont, Emmanuel
- Dowell, Simon
- Cryan, Jenni
- Morse, Mary
- Patel, Aarti
- Garden, Helen
- Witherington, Jason
Producer: 20121001
In:
Xenobiotica; the fate of foreign compounds in biological systems vol. 42
Availability: No items available.
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5.
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Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist. [electronic resource] by
- Stean, Tania O
- Hirst, Warren D
- Thomas, David R
- Price, Gary W
- Rogers, Derek
- Riley, Graham
- Bromidge, Steven M
- Serafinowska, Halina T
- Smith, Douglas R
- Bartlett, Sarah
- Deeks, Nigel
- Duxon, Mark
- Upton, Neil
Producer: 20020911
In:
Pharmacology, biochemistry, and behavior vol. 71
Availability: No items available.
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SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats. [electronic resource] by
- Thomas, David R
- Melotto, Sergio
- Massagrande, Mario
- Gribble, Andrew D
- Jeffrey, Phillip
- Stevens, Alexander J
- Deeks, Nigel J
- Eddershaw, Peter J
- Fenwick, Susan H
- Riley, Graham
- Stean, Tania
- Scott, Claire M
- Hill, Matthew J
- Middlemiss, Derek N
- Hagan, Jim J
- Price, Gary W
- Forbes, Ian T
Producer: 20040324
In:
British journal of pharmacology vol. 139
Availability: No items available.
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7.
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Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists. [electronic resource] by
- Trani, Giancarlo
- Baddeley, Stuart M
- Briggs, Michael A
- Chuang, Tsu T
- Deeks, Nigel J
- Johnson, Christopher N
- Khazragi, Abir A
- Mead, Tania L
- Medhurst, Andrew D
- Milner, Peter H
- Quinn, Leann P
- Ray, Alison M
- Rivers, Dean A
- Stean, Tania O
- Stemp, Geoffrey
- Trail, Brenda K
- Witty, David R
Producer: 20090424
In:
Bioorganic & medicinal chemistry letters vol. 18
Availability: No items available.
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8.
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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists. [electronic resource] by
- Ahmed, Mahmood
- Briggs, Michael A
- Bromidge, Steven M
- Buck, Tania
- Campbell, Lorraine
- Deeks, Nigel J
- Garner, Ashley
- Gordon, Laurie
- Hamprecht, Dieter W
- Holland, Vicky
- Johnson, Christopher N
- Medhurst, Andrew D
- Mitchell, Darren J
- Moss, Stephen F
- Powles, Jenifer
- Seal, Jon T
- Stean, Tania O
- Stemp, Geoffrey
- Thompson, Mervyn
- Trail, Brenda
- Upton, Neil
- Winborn, Kim
- Witty, David R
Producer: 20051223
In:
Bioorganic & medicinal chemistry letters vol. 15
Availability: No items available.
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9.
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Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate. [electronic resource] by
- Demont, Emmanuel H
- Andrews, Benjamin I
- Bit, Rino A
- Campbell, Colin A
- Cooke, Jason W B
- Deeks, Nigel
- Desai, Sapna
- Dowell, Simon J
- Gaskin, Pam
- Gray, James R J
- Haynes, Andrea
- Holmes, Duncan S
- Kumar, Umesh
- Morse, Mary A
- Osborne, Greg J
- Panchal, Terry
- Patel, Bela
- Perboni, Alcide
- Taylor, Simon
- Watson, Robert
- Witherington, Jason
- Willis, Robert
Producer: 20140605
In:
ACS medicinal chemistry letters vol. 2
Availability: No items available.
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10.
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Discovery of a brain-penetrant S1P₃-sparing direct agonist of the S1P₁ and S1P₅ receptors efficacious at low oral dose. [electronic resource] by
- Demont, Emmanuel H
- Arpino, Sandra
- Bit, Rino A
- Campbell, Colin A
- Deeks, Nigel
- Desai, Sapna
- Dowell, Simon J
- Gaskin, Pam
- Gray, James R J
- Harrison, Lee A
- Haynes, Andrea
- Heightman, Tom D
- Holmes, Duncan S
- Humphreys, Philip G
- Kumar, Umesh
- Morse, Mary A
- Osborne, Greg J
- Panchal, Terry
- Philpott, Karen L
- Taylor, Simon
- Watson, Robert
- Willis, Robert
- Witherington, Jason
Producer: 20111212
In:
Journal of medicinal chemistry vol. 54
Availability: No items available.
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11.
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Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses. [electronic resource] by
- Demont, Emmanuel H
- Bailey, James M
- Bit, Rino A
- Brown, Jack A
- Campbell, Colin A
- Deeks, Nigel
- Dowell, Simon J
- Eldred, Colin
- Gaskin, Pam
- Gray, James R J
- Haynes, Andrea
- Hirst, David J
- Holmes, Duncan S
- Kumar, Umesh
- Morse, Mary A
- Osborne, Greg J
- Renaux, Jessica F
- Seal, Gail A L
- Smethurst, Chris A
- Taylor, Simon
- Watson, Robert
- Willis, Robert
- Witherington, Jason
Producer: 20160712
In:
Journal of medicinal chemistry vol. 59
Availability: No items available.
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